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KMID : 1143620160200020009
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Korean Journal of Nuclear Medicine Technology
2016 Volume.20 No. 2 p.9 ~ p.13
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Clinical Application of 11C-Acetate Positron Emission Tomography-Computed Tomography (PET-CT) in Patients of Urinary System Cancer
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Namkoong Hyuk
Ham Joon-Chul
Kim Sang-Kyoo
Choi Yong-Hoon
Lim Han-Sang
Kim Jae-Sam
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Abstract
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Purpose : PET-CT examinations using 18F-FDG to treat urinary system cancer are limited in terms of anatomical structure
and excretion route of 18F-FDG. But one of the ongoing examinations utilizing 11C-Acetate can compensate for such defects. We would like to introduce a clinical application of 11C-Acetate PET-CT in urinary cancer patients.
Materials and Methods : We conducted a clinical survey of 22 patients diagnosed with urinary cancer at our hospital, 10 prostate cancer patients, 10 renal cell carcinoma patients, and 2 bladder cancer patients. All patients were performed 18F-FDG PET-CT examinations, 11C-Acetate examinations were performed after two weeks on average. The equipment
used to D-710 PET-CT in GE Company and we performed PET-CT procedures 15 minutes after injecting 11C-Acetate, and a medical doctor from the department of nuclear medicine appraised and compared images between 18F-FDG and 11C-Acetate.
Results : According to our survey, prostate cancer patients generally had lower uptake of 18F-FDG than other cancer patients did. In 2 out of 10 prostate cancer patients, metastasized cancer showed greater uptake in 11C-Acetate than 18F-FDG. In renal cell carcinoma cases, 8 out of 10 patients displayed evidently greater uptake in 11C-Acetate than 18F-FDG. We excluded bladder cancer cases in this study because uptake of 18F-FDG in the bladder was too hot, the number of patients was insufficient, and the cases did not meet criteria such as the use of diuretics.
Conclusion : It is too premature to draw solid conclusions from the survey, since it involved only a small number of
participants. However, there are a number of studies conducted abroad that prove the effectiveness of the 11C-Acetate PET-CT examinations in treating urinary system cancer, and this study is still ongoing at our hospital. If the tests were to be conducted on a larger number of participants, this study could lead to numerous other potential research topics, such as the correlation between Prostatic specific antigen (PSA) values and 11C-Acetate PET-CT, Gleason sum values from biopsy before surgery, Specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV) between 18F-FDG PET-CT examinations and 11C-Acetate PET-CT examinations in other urinary system cancers.
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KEYWORD
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urinary system cancer, acetate, 11C-Acetate PET-CT
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